Volume of distribution (Vd) is a pharmacokinetic parameter that quantifies the extent to which a drug disperses throughout the body's fluids and tissues relative to its concentration in the bloodstream. This value helps predict how well a drug will be distributed in the body after absorption and indicates how effectively it reaches target tissues. Understanding Vd is essential in determining dosing regimens and evaluating the drug's ability to cross biological barriers, particularly when it comes to central nervous system penetration and ADMET properties.
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