Sofosbuvir

Definition

Sofosbuvir is an antiviral medication used to treat hepatitis C virus (HCV) infection. It inhibits the HCV NS5B RNA-dependent RNA polymerase, which is essential for viral replication.

5 Must Know Facts For Your Next Test

1. Sofosbuvir is often combined with other antiviral medications for a more effective treatment regimen.
2. It has a high barrier to resistance, making it a key component in HCV therapy.
3. Sofosbuvir is administered orally and is usually taken once daily.
4. The drug is metabolized in the liver and excreted primarily through the kidneys.
5. Common side effects include fatigue, headache, and nausea.

Review Questions

• What enzyme does Sofosbuvir inhibit to prevent HCV replication?
• How is Sofosbuvir typically administered?
• What are some common side effects of Sofosbuvir?

Related terms

Hepatitis C Virus (HCV): A viral infection that causes liver inflammation and can lead to serious liver damage.

NS5B RNA-dependent RNA polymerase: An enzyme crucial for the replication of the hepatitis C virus.

Ribavirin: An antiviral medication often used in combination with other drugs to treat hepatitis C.