Sofosbuvir is an antiviral medication used primarily to treat hepatitis C virus (HCV) infections. It functions as a nucleotide analog inhibitor of the HCV RNA polymerase.
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Sofosbuvir inhibits the RNA-dependent RNA polymerase, which is essential for viral replication.
It is often used in combination with other antiviral drugs for increased efficacy.
Sofosbuvir has a high barrier to resistance compared to other HCV medications.
Common side effects include fatigue, headache, and nausea.
It was approved by the FDA in 2013 for the treatment of chronic hepatitis C.
Review Questions
What is the primary mechanism of action of sofosbuvir?
Why is sofosbuvir typically used in combination with other antiviral medications?
What are some common side effects associated with sofosbuvir?
Related terms
Hepatitis C Virus (HCV): A viral infection that causes liver inflammation and can lead to serious liver damage.
RNA-dependent RNA Polymerase: An enzyme that catalyzes the replication of RNA from an RNA template, crucial for the replication of RNA viruses like HCV.
Antiviral Medication: Drugs designed to treat viral infections by inhibiting the development and spread of viruses within the host body.