Raltegravir

Definition

Raltegravir is an antiretroviral drug used to treat HIV infection by inhibiting the integration of viral DNA into the host cell genome. It belongs to a class of drugs known as integrase strand transfer inhibitors (INSTIs).

5 Must Know Facts For Your Next Test

1. Raltegravir was the first integrase inhibitor approved for the treatment of HIV.
2. It is typically used in combination with other antiretrovirals for a more effective HIV treatment regimen.
3. The drug is metabolized primarily through glucuronidation, not cytochrome P450 enzymes.
4. Common side effects include nausea, headache, and fatigue.
5. Raltegravir is available in both tablet and chewable forms, allowing for flexible dosing.

Review Questions

• What class of antiretroviral drugs does Raltegravir belong to?
• How does Raltegravir work to inhibit HIV replication?
• What are some common side effects associated with Raltegravir?

Related terms

Integrase Strand Transfer Inhibitors (INSTIs): A class of antiretroviral drugs that prevent the integration of viral DNA into the host cell genome.

HIV: Human Immunodeficiency Virus, a virus that attacks the immune system and can lead to AIDS.

Glucuronidation: A metabolic pathway that involves adding glucuronic acid to substances for detoxification and excretion.