Raltegravir

Definition

Raltegravir is an antiretroviral drug used to inhibit the integrase enzyme, preventing the integration of HIV DNA into the host cell genome. It is primarily used in the treatment of HIV/AIDS.

5 Must Know Facts For Your Next Test

1. Raltegravir is classified as an integrase strand transfer inhibitor (INSTI).
2. It specifically targets and inhibits the HIV-1 integrase enzyme.
3. Raltegravir was the first FDA-approved drug in its class, approved in 2007.
4. It is often used in combination with other antiretroviral medications for a more effective treatment regimen.
5. Resistance to raltegravir can develop through mutations in the integrase gene of HIV.

Review Questions

• What class of drugs does raltegravir belong to?
• How does raltegravir inhibit HIV replication?
• Why is raltegravir usually combined with other antiretroviral medications?

Related terms

Integrase Inhibitor: A class of antiretroviral drugs that block the action of integrase, an enzyme required for viral replication.

HIV-1 Integrase: An enzyme that facilitates the integration of viral DNA into the host cell's genome.

Antiretroviral Therapy (ART): The use of multiple antiretroviral drugs to treat HIV infection and prevent progression to AIDS.