Lansoprazole

Definition

Lansoprazole is a proton-pump inhibitor (PPI) that decreases the amount of acid produced in the stomach. It is commonly used to treat conditions like GERD, ulcers, and Zollinger-Ellison syndrome.

5 Must Know Facts For Your Next Test

1. Lansoprazole inhibits the H+/K+ ATPase enzyme system of gastric parietal cells.
2. It is often administered orally and can be taken with or without food.
3. Common side effects include headache, nausea, diarrhea, and abdominal pain.
4. Long-term use may lead to vitamin B12 deficiency and increased risk of bone fractures.
5. Lansoprazole can interact with drugs like warfarin, methotrexate, and certain antifungals.

Review Questions

• What enzyme system does lansoprazole inhibit to reduce stomach acid production?
• What are some common side effects associated with lansoprazole?
• Why might long-term use of lansoprazole lead to vitamin B12 deficiency?

Related terms

Omeprazole: A proton-pump inhibitor used to treat similar conditions as lansoprazole by reducing stomach acid.

Ranitidine: A histamine-2 blocker that decreases stomach acid production differently than PPIs.

GERD: Gastroesophageal reflux disease, a condition that lansoprazole helps manage by reducing stomach acid.