Hepatotoxicity

Definition

Hepatotoxicity is the occurrence of liver damage due to exposure to drugs or other substances. It is a critical consideration when evaluating the safety profile of antimicrobial drugs.

5 Must Know Facts For Your Next Test

1. Hepatotoxicity can result from both over-the-counter and prescription medications, including some antimicrobial drugs.
2. Symptoms of hepatotoxicity may include jaundice, fatigue, abdominal pain, and elevated liver enzymes.
3. Common antimicrobial agents associated with hepatotoxicity include isoniazid, rifampin, and certain antifungal medications.
4. Monitoring liver function tests (LFTs) is essential when patients are on long-term antimicrobial therapy.
5. Genetic factors and pre-existing liver conditions can increase the risk of drug-induced hepatotoxicity.

Review Questions

• What are some common symptoms of hepatotoxicity?
• Which antimicrobial drugs are frequently linked to hepatotoxicity?
• Why is it important to monitor liver function tests in patients undergoing long-term antimicrobial therapy?

Related terms

Antimicrobial Drugs: Medications used to treat infections caused by microorganisms such as bacteria, viruses, fungi, and parasites.

Liver Function Tests (LFTs): A group of blood tests that provide information about the state of a patient's liver.

Adverse Drug Reaction (ADR): An unwanted or harmful reaction experienced following the administration of a drug or combination of drugs under normal conditions.