Hepatotoxicity

Definition

Hepatotoxicity is the occurrence of liver damage due to exposure to certain substances, such as medications or toxins. It can lead to impaired liver function and, in severe cases, liver failure.

5 Must Know Facts For Your Next Test

1. Common medications for neurological conditions, such as anticonvulsants and antipsychotics, can cause hepatotoxicity.
2. Early symptoms of hepatotoxicity may include jaundice, fatigue, and abdominal pain.
3. Liver function tests (LFTs) are critical for monitoring patients on long-term medication therapy to detect hepatotoxicity early.
4. Nutritional status can influence susceptibility to hepatotoxicity; malnutrition can exacerbate liver damage.
5. Management of hepatotoxicity involves discontinuing the offending drug and providing supportive care to promote liver recovery.

Review Questions

• What are some early symptoms that may indicate hepatotoxicity?
• Why are liver function tests important for patients taking long-term neurological medications?
• How does nutritional status impact the risk of developing hepatotoxicity?

Related terms

Liver Function Tests (LFTs): Blood tests used to assess the health and functionality of the liver.

Anticonvulsants:

Medications used to prevent seizures that can have side effects including hepatotoxicity.

Malnutrition:

A state resulting from a lack of proper nutrition that can increase vulnerability to various health issues, including hepatotoxicity.