Zetia

Definition

Zetia (ezetimibe) is a medication used to lower cholesterol levels by inhibiting the absorption of cholesterol in the small intestine. It is often prescribed alongside statins or other lipid-lowering drugs to enhance cholesterol reduction.

5 Must Know Facts For Your Next Test

1. Zetia works by targeting and blocking the Niemann-Pick C1-Like 1 (NPC1L1) protein on the brush border of the small intestine, reducing intestinal cholesterol absorption.
2. It is primarily used for patients who cannot control their cholesterol levels through diet and exercise alone.
3. Common side effects include gastrointestinal issues such as diarrhea and abdominal pain.
4. Zetia can be used as monotherapy or in combination with statins for a synergistic effect on lowering LDL-cholesterol levels.
5. Ezetimibe has minimal impact on triglycerides and HDL-cholesterol compared to its significant effect on lowering LDL-cholesterol.

Review Questions

• How does Zetia lower cholesterol levels in the body?
• What are common side effects associated with taking Zetia?
• Why might a clinician prescribe Zetia in combination with a statin?

Related terms

Statins: A class of drugs that lower blood cholesterol levels by inhibiting HMG-CoA reductase.

LDL-Cholesterol: Low-density lipoprotein that carries cholesterol to cells, often referred to as 'bad' cholesterol.

Niemann-Pick C1-Like 1 (NPC1L1): A protein involved in the intestinal absorption of dietary and biliary cholesterol.