Zaroxolyn

Definition

Zaroxolyn, also known as metolazone, is a thiazide-like diuretic used to manage hypertension and edema associated with heart failure. It works by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron.

5 Must Know Facts For Your Next Test

1. Zaroxolyn is particularly effective in patients with reduced kidney function compared to other thiazide diuretics.
2. The drug can cause electrolyte imbalances, such as hypokalemia and hyponatremia.
3. It is often used in combination with loop diuretics for synergistic effects in severe cases of fluid retention.
4. Common side effects include dizziness, dehydration, and muscle cramps.
5. Zaroxolyn is usually administered orally and absorbed well from the gastrointestinal tract.

Review Questions

• What type of diuretic is Zaroxolyn classified as?
• Why might Zaroxolyn be preferred in patients with impaired kidney function?
• What are common electrolyte imbalances associated with Zaroxolyn?

Related terms

Thiazide Diuretics: A class of drugs that inhibit sodium reabsorption at the beginning of the distal convoluted tubule.

Loop Diuretics: Diuretics that act on the ascending limb of the loop of Henle to inhibit sodium and chloride reabsorption.

Hypokalemia: A condition characterized by low levels of potassium in the blood, often a side effect of certain diuretics.