Xarelto

Definition

Xarelto is an oral anticoagulant that inhibits Factor Xa to prevent blood clot formation. It is commonly used to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.

5 Must Know Facts For Your Next Test

1. Xarelto (rivaroxaban) works by inhibiting Factor Xa, a key enzyme in the coagulation pathway.
2. It is used for the prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE) following knee or hip replacement surgery.
3. Unlike warfarin, Xarelto does not require routine INR monitoring.
4. The primary adverse effects include bleeding complications such as gastrointestinal bleeding and hemorrhage.
5. Xarelto should be taken with food to increase its absorption.

Review Questions

• What is the mechanism of action for Xarelto?
• For which conditions is Xarelto commonly prescribed?
• Why does Xarelto not require routine INR monitoring compared to warfarin?

Related terms

Warfarin: An oral anticoagulant that inhibits vitamin K-dependent clotting factors.

Factor Xa Inhibitors: A class of anticoagulants that work by inhibiting Factor Xa, crucial in the coagulation cascade.

Deep Vein Thrombosis (DVT): The formation of a blood clot in a deep vein, usually in the legs.