Torsemide

Definition

Torsemide is a loop diuretic used to treat edema associated with heart failure, liver disease, and kidney disease. It works by inhibiting the sodium-potassium-chloride co-transporter in the thick ascending limb of the loop of Henle.

5 Must Know Facts For Your Next Test

1. Torsemide is more potent and has a longer duration of action compared to furosemide.
2. It can be administered orally or intravenously.
3. Common side effects include electrolyte imbalances, dehydration, and hypotension.
4. Torsemide is metabolized by the liver via cytochrome P450 enzymes.
5. It's often used in patients who are resistant to other diuretics like furosemide.

Review Questions

• What is the primary mechanism of action for Torsemide?
• List two common side effects of Torsemide.
• How does Torsemide compare to furosemide in terms of potency and duration?

Related terms

Furosemide: A loop diuretic commonly used to treat edema and hypertension.

Spironolactone: A potassium-sparing diuretic that antagonizes aldosterone in the distal tubules.

Hydrochlorothiazide: A thiazide diuretic that inhibits sodium reabsorption in the distal convoluted tubule.