TNKase

Definition

TNKase (tenecteplase) is a genetically engineered variant of tissue plasminogen activator (tPA) used as a thrombolytic agent. It is administered to dissolve blood clots in the treatment of acute myocardial infarction.

5 Must Know Facts For Your Next Test

1. TNKase is administered as a single intravenous bolus, unlike other thrombolytics that require prolonged infusions.
2. It works by converting plasminogen to plasmin, which then degrades fibrin and dissolves the clot.
3. TNKase has a longer half-life than alteplase, allowing for its single-bolus administration.
4. Common side effects include bleeding complications, with intracranial hemorrhage being the most serious risk.
5. It is contraindicated in patients with active internal bleeding, recent stroke, or severe uncontrolled hypertension.

Review Questions

• What is the mechanism of action of TNKase?
• Why is TNKase preferred over other thrombolytics in terms of administration?
• What are some major contraindications for using TNKase?

Related terms

tissue plasminogen activator (tPA): An enzyme involved in the breakdown of blood clots.

acute myocardial infarction: A condition where blood flow to the heart muscle is abruptly cut off, causing tissue damage.

alteplase: A recombinant form of tPA used as a thrombolytic agent but requires continuous infusion.