Ticagrelor

Definition

Ticagrelor is an oral antiplatelet medication used to reduce the risk of cardiovascular events such as heart attacks and strokes. It works by inhibiting the P2Y12 receptor on platelets, preventing platelet aggregation.

5 Must Know Facts For Your Next Test

1. Ticagrelor is often prescribed for patients with acute coronary syndrome (ACS).
2. It has a faster onset and offset of action compared to clopidogrel.
3. Common side effects include dyspnea, bleeding, and increased serum uric acid.
4. Ticagrelor should not be used in patients with active pathological bleeding or a history of intracranial hemorrhage.
5. Concurrent use with strong CYP3A4 inhibitors can increase ticagrelor levels and risks.

Review Questions

• What receptor does Ticagrelor inhibit to prevent platelet aggregation?
• Why might Ticagrelor be preferred over clopidogrel in some patients?
• List two common side effects associated with Ticagrelor.

Related terms

Clopidogrel: An antiplatelet drug that inhibits ADP receptors on platelets, commonly used for similar indications as Ticagrelor.

Acute Coronary Syndrome (ACS): A term encompassing conditions like heart attack and unstable angina due to reduced blood flow to the heart.

CYP3A4 Inhibitors: Drugs that inhibit the CYP3A4 enzyme, potentially increasing plasma levels of medications metabolized by this pathway, including Ticagrelor.