Tenecteplase

Definition

Tenecteplase is a recombinant tissue plasminogen activator (rtPA) used as a thrombolytic agent. It is primarily administered to dissolve blood clots in patients experiencing acute myocardial infarction.

5 Must Know Facts For Your Next Test

1. Tenecteplase has a longer half-life compared to alteplase, allowing for single bolus administration.
2. It works by binding to fibrin and converting plasminogen to plasmin, leading to the breakdown of clots.
3. Tenecteplase is contraindicated in patients with active internal bleeding or history of hemorrhagic stroke.
4. Common side effects include bleeding, hypotension, and allergic reactions.
5. It is often given in conjunction with anticoagulants and antiplatelet agents for optimal efficacy.

Review Questions

• What is the primary medical use of Tenecteplase?
• How does Tenecteplase differ from alteplase in terms of administration?
• What are the major contraindications for using Tenecteplase?

Related terms

Alteplase: Another rtPA used as a thrombolytic agent, requiring multiple administrations.

Heparin: An anticoagulant often used alongside thrombolytics to prevent new clot formation.

Aspirin: An antiplatelet drug commonly administered with thrombolytics to improve outcomes in myocardial infarction.