Sildenafil

Definition

Sildenafil is a medication commonly used to treat erectile dysfunction and pulmonary arterial hypertension. It works by inhibiting phosphodiesterase type 5 (PDE5), thereby enhancing the effects of nitric oxide and increasing blood flow.

5 Must Know Facts For Your Next Test

1. Sildenafil is marketed under the brand name Viagra for erectile dysfunction.
2. It should be taken about 30 minutes to 4 hours before sexual activity, but not more than once daily.
3. Common side effects include headaches, flushing, indigestion, nasal congestion, and impaired vision.
4. Sildenafil should not be used in combination with nitrates due to the risk of severe hypotension.
5. The drug was originally developed for hypertension and angina pectoris before its use for erectile dysfunction was discovered.

Review Questions

• What is the primary mechanism of action for sildenafil?
• List two common side effects associated with sildenafil use.
• Why should sildenafil not be taken with nitrate medications?

Related terms

Tadalafil: A PDE5 inhibitor used to treat erectile dysfunction and benign prostatic hyperplasia.

Vardenafil: Another PDE5 inhibitor that treats erectile dysfunction.

Nitric Oxide: A molecule involved in vasodilation and the mechanism through which sildenafil increases blood flow.