Serotonin agonists

Definition

Serotonin agonists are drugs that activate serotonin receptors, mimicking the effects of serotonin. They are commonly used to treat migraine headaches by constricting blood vessels and inhibiting pain pathways.

5 Must Know Facts For Your Next Test

1. Serotonin agonists, such as triptans, are effective in aborting acute migraine attacks.
2. These medications work by binding to 5-HT1B and 5-HT1D receptors, leading to vasoconstriction.
3. Common side effects include dizziness, tingling, and sensations of warmth or cold.
4. They should be used cautiously in patients with cardiovascular diseases due to their vasoconstrictive properties.
5. Triptans are contraindicated in patients taking monoamine oxidase inhibitors (MAOIs).

Review Questions

• What receptor types do serotonin agonists primarily target?
• What are common side effects associated with serotonin agonists?
• Why must caution be exercised when prescribing serotonin agonists to patients with cardiovascular diseases?

Related terms

Migraine: A neurological condition characterized by intense, debilitating headaches often accompanied by nausea and sensitivity to light.

Triptans: A class of drugs that act as serotonin receptor agonists specifically targeting 5-HT1B and 5-HT1D receptors.

Vasoconstriction: The narrowing of blood vessels resulting from contraction of the muscular wall of the vessels.