Rosuvastatin

Definition

Rosuvastatin is a statin medication used to lower cholesterol levels and reduce the risk of cardiovascular diseases. It works by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver.

5 Must Know Facts For Your Next Test

1. Rosuvastatin is often prescribed to patients with high LDL cholesterol or those at risk for atherosclerosis.
2. It can lead to side effects like muscle pain, liver damage, and increased blood sugar levels.
3. Rosuvastatin is metabolized primarily in the liver and has a long half-life compared to other statins.
4. Patients taking rosuvastatin should avoid grapefruit juice as it can increase drug levels and risk of side effects.
5. Dosage adjustments may be necessary for patients with renal impairment or those taking certain other medications.

Review Questions

• What enzyme does rosuvastatin inhibit to lower cholesterol levels?
• Name two potential side effects of taking rosuvastatin.
• Why should patients on rosuvastatin avoid consuming grapefruit juice?

Related terms

Statins:

A class of drugs used to lower cholesterol levels by inhibiting HMG-CoA reductase.

PCSK9 Inhibitors:

Medications that help lower LDL cholesterol by increasing the number of LDL receptors available to clear LDL from the blood.

HMG-CoA Reductase:

The enzyme targeted by statins to reduce cholesterol synthesis in the liver.