Rivaroxaban

Definition

Rivaroxaban is an oral anticoagulant that selectively inhibits Factor Xa, preventing the formation of blood clots. It is commonly used to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.

5 Must Know Facts For Your Next Test

1. Rivaroxaban does not require routine coagulation monitoring like warfarin.
2. It is metabolized primarily in the liver via CYP3A4/5 pathways.
3. The drug has a rapid onset of action, typically within 2-4 hours after oral administration.
4. Rivaroxaban is contraindicated in patients with significant active bleeding or severe hepatic impairment.
5. Antidote for Rivaroxaban overdose or uncontrolled bleeding is Andexanet alfa.

Review Questions

• What enzyme primarily metabolizes Rivaroxaban?
• Why does Rivaroxaban not require routine coagulation monitoring?
• What is the antidote for a Rivaroxaban overdose?

Related terms

Warfarin: An oral anticoagulant that requires regular INR monitoring to ensure therapeutic levels.

Heparin: An injectable anticoagulant used for immediate anticoagulation, often monitored by aPTT.

Andexanet alfa: A reversal agent specifically used to counteract the effects of Factor Xa inhibitors like Rivaroxaban.