Rituximab

Definition

Rituximab is a monoclonal antibody used to treat certain autoimmune diseases and types of cancer. It targets the CD20 protein on the surface of B cells, leading to their destruction.

5 Must Know Facts For Your Next Test

1. It is commonly used in the treatment of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
2. Rituximab works by binding to the CD20 antigen on B cells, causing cell death.
3. It can be administered intravenously and requires monitoring for infusion-related reactions.
4. Common side effects include fever, chills, weakness, nausea, and infections due to immunosuppression.
5. Rituximab may also be used off-label for conditions like rheumatoid arthritis and multiple sclerosis.

Review Questions

• What type of protein does Rituximab target on B cells?
• For which types of cancer is Rituximab primarily used?
• What are some common side effects associated with Rituximab therapy?

Related terms

Monoclonal Antibodies: Laboratory-made molecules that can mimic the immune system's ability to fight off harmful pathogens.

Immunosuppressants: Drugs that inhibit or prevent activity of the immune system.

Biologic Response Modifiers: Substances that enhance or suppress the immune response to help fight infections and diseases like cancer.