Propafenone

Definition

Propafenone is a Class IC antiarrhythmic drug used to treat certain types of serious irregular heartbeats. It works by blocking sodium channels in the cardiac cells, stabilizing the heart rhythm.

5 Must Know Facts For Your Next Test

1. Propafenone is primarily used to treat atrial fibrillation and ventricular arrhythmias.
2. It has both beta-blocking and weak calcium channel blocking effects.
3. Common side effects include dizziness, metallic taste, and gastrointestinal disturbances.
4. It is metabolized by the liver, specifically through the cytochrome P450 pathway.
5. Caution is advised in patients with structural heart disease due to the risk of proarrhythmia.

Review Questions

• What type of arrhythmias is Propafenone commonly used to treat?
• Describe the additional pharmacological effects of Propafenone besides sodium channel blocking.
• Why should caution be exercised when prescribing Propafenone to patients with structural heart disease?

Related terms

Atrial Fibrillation: A common type of arrhythmia characterized by irregular and often rapid heart rate.

Ventricular Arrhythmias: Abnormal heart rhythms originating from the ventricles, which can be life-threatening.

Cytochrome P450 Pathway: A key enzyme system in the liver responsible for metabolizing many drugs, including Propafenone.