Pradaxa

Definition

Pradaxa (dabigatran) is an oral anticoagulant that inhibits thrombin, a key enzyme in the blood clotting process. It is commonly used to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation.

5 Must Know Facts For Your Next Test

1. Pradaxa directly inhibits thrombin, preventing the conversion of fibrinogen to fibrin.
2. It is taken orally and does not require routine INR monitoring like warfarin.
3. The most common side effect of Pradaxa is bleeding, including gastrointestinal bleeding.
4. Pradaxa has a specific reversal agent called idarucizumab (Praxbind) for emergency situations involving severe bleeding.
5. Patients with impaired renal function may require dose adjustments or alternative therapies due to the drug's renal clearance.

Review Questions

• What enzyme does Pradaxa inhibit to exert its anticoagulant effects?
• Why might Pradaxa be preferred over warfarin for some patients?
• What is the name of the reversal agent for Pradaxa?

Related terms

Warfarin: An oral anticoagulant that works by inhibiting vitamin K-dependent clotting factors.

Thrombin: An enzyme that plays a central role in the blood coagulation cascade by converting fibrinogen to fibrin.

Idarucizumab: A monoclonal antibody fragment that acts as a reversal agent for Pradaxa in cases of emergency bleeding.