Polyenes
from class: Pharmacology for Nurses Definition Polyenes are a class of antifungal drugs that target fungal cell membranes by binding to ergosterol, a key component. This disrupts membrane integrity, leading to fungal cell death.
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Predict what's on your test 5 Must Know Facts For Your Next Test Polyenes are primarily used to treat serious systemic fungal infections. The most commonly known polyene is Amphotericin B. Polyenes can be administered intravenously due to their poor absorption in the gastrointestinal tract. They have a broad spectrum of activity against various fungi, including Candida and Aspergillus species. Common side effects include nephrotoxicity and infusion-related reactions. Review Questions What is the primary mechanism of action for polyenes? Name one common polyene used in clinical practice. What are some potential side effects associated with polyene administration? "Polyenes" also found in:
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