Pitavastatin

Definition

Pitavastatin is a lipid-lowering medication belonging to the statin class, used to reduce cholesterol levels. It works by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol synthesis in the liver.

5 Must Know Facts For Your Next Test

1. Pitavastatin is particularly effective in lowering low-density lipoprotein (LDL) cholesterol.
2. It is metabolized minimally by the cytochrome P450 system, which reduces its potential for drug interactions.
3. Common side effects include muscle pain and gastrointestinal issues such as nausea and diarrhea.
4. Pitavastatin has a relatively long half-life compared to other statins, allowing for once-daily dosing.
5. It is contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases.

Review Questions

• What enzyme does Pitavastatin inhibit to lower cholesterol levels?
• Why might Pitavastatin have fewer drug interactions compared to other statins?
• What are some common side effects associated with Pitavastatin?

Related terms

Statins: A class of drugs that reduce cholesterol levels by inhibiting HMG-CoA reductase.

HMG-CoA Reductase Inhibitors: Another term for statins, indicating their mechanism of action.

PCSK9 Inhibitors: A newer class of drugs that lower LDL cholesterol by increasing the number of LDL receptors on liver cells.