Pioglitazone

Definition

Pioglitazone is an oral antidiabetic drug that belongs to the thiazolidinedione class. It helps improve insulin sensitivity in patients with type 2 diabetes.

5 Must Know Facts For Your Next Test

1. Pioglitazone activates PPAR-gamma receptors, enhancing insulin sensitivity in muscle and adipose tissue.
2. It is usually taken once daily, with or without food.
3. Common side effects include weight gain, edema, and an increased risk of heart failure.
4. Pioglitazone can interact with other medications such as oral contraceptives and corticosteroids.
5. It is contraindicated in patients with severe heart failure or active bladder cancer.

Review Questions

• What class of drugs does Pioglitazone belong to?
• How does Pioglitazone enhance insulin sensitivity?
• What are some common side effects associated with Pioglitazone?

Related terms

Metformin: An oral antidiabetic drug that decreases hepatic glucose production and increases insulin sensitivity.

Sulfonylureas: A class of oral antidiabetic drugs that stimulate pancreatic beta cells to release more insulin.

DPP-4 Inhibitors: Oral antidiabetic drugs that enhance the activity of incretin hormones, increasing insulin release and decreasing glucagon levels.