Mycophenolate

Definition

Mycophenolate is an immunosuppressant drug commonly used to prevent organ rejection in transplant patients. It works by inhibiting the proliferation of lymphocytes, which are crucial for the immune response.

5 Must Know Facts For Your Next Test

1. Mycophenolate selectively inhibits inosine monophosphate dehydrogenase (IMPDH), crucial for guanine nucleotide synthesis in T and B lymphocytes.
2. It is often used in combination with other immunosuppressants such as cyclosporine or tacrolimus to enhance efficacy.
3. Common side effects include gastrointestinal disturbances, leukopenia, and increased risk of infections.
4. Patients taking mycophenolate must be regularly monitored for signs of infection and blood cell counts.
5. It is contraindicated in pregnant women due to its teratogenic effects.

Review Questions

• What enzyme does mycophenolate inhibit to exert its immunosuppressive effects?
• Why is mycophenolate often used in combination with other immunosuppressants?
• What are some common side effects associated with mycophenolate?

Related terms

Cyclosporine: An immunosuppressant drug that inhibits calcineurin, reducing T-cell activity.

Tacrolimus: An immunosuppressant that binds to FK506-binding protein to inhibit calcineurin, thereby suppressing T-cell activation.

Inflammatory Response: A biological response involving immune cells, blood vessels, and molecular mediators to eliminate harmful stimuli.