Mafenide acetate

Definition

Mafenide acetate is a topical sulfonamide antibiotic used primarily to treat second and third-degree burns. It helps prevent bacterial infections in burn wounds.

5 Must Know Facts For Your Next Test

1. Mafenide acetate is effective against a broad range of Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa.
2. It penetrates burn eschar, ensuring the drug reaches underlying tissues where bacteria may reside.
3. Common side effects include pain or burning upon application and metabolic acidosis due to carbonic anhydrase inhibition.
4. Mafenide acetate is usually applied twice daily after cleaning the burn wound thoroughly.
5. It should not be used in patients who are allergic to sulfonamides or have pre-existing renal impairment.

Review Questions

• What types of burns is Mafenide acetate primarily used to treat?
• List two common side effects of Mafenide acetate.
• Why should Mafenide acetate not be used in patients with renal impairment?

Related terms

Silver sulfadiazine: A topical antimicrobial agent widely used for preventing and treating infections in burn wounds.

Bacitracin: An antibiotic ointment that prevents minor skin infections caused by small cuts, scrapes, or burns.

Escharotomy: A surgical procedure where incisions are made through the eschar to relieve pressure and improve blood flow in severe burn cases.