Lovastatin
from class:
Pharmacology for Nurses
Definition
Lovastatin is a statin medication used primarily to lower cholesterol levels and reduce the risk of cardiovascular disease. It works by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol synthesis in the liver.
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5 Must Know Facts For Your Next Test
- Lovastatin is metabolized in the liver primarily via the CYP3A4 pathway.
- Common side effects include muscle pain, digestive problems, and increased liver enzymes.
- It is often taken in the evening because cholesterol synthesis occurs predominantly at night.
- The drug is contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases.
- Grapefruit juice can increase lovastatin levels in the blood, leading to a higher risk of adverse effects.
Review Questions
- What enzyme does lovastatin inhibit to lower cholesterol?
- Why should lovastatin generally be taken in the evening?
- What are common side effects associated with lovastatin use?
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