Linaclotide

Definition

Linaclotide is a guanylate cyclase-C agonist used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). It works by increasing the secretion of chloride and water in the intestines, which helps ease bowel movements.

5 Must Know Facts For Your Next Test

1. Linaclotide is taken orally, usually once daily on an empty stomach.
2. It can cause diarrhea as a common side effect, sometimes severe enough to require discontinuation.
3. The medication is not recommended for use in patients younger than 18 years old due to lack of safety data.
4. Linaclotide works by activating guanylate cyclase-C receptors on the surface of intestinal epithelial cells.
5. It should not be used in individuals with known or suspected mechanical gastrointestinal obstruction.

Review Questions

• What are the primary conditions treated by linaclotide?
• How does linaclotide function at a cellular level?
• What is a major contraindication for the use of linaclotide?

Related terms

Guanylate Cyclase-C Agonist: A class of drugs that activates guanylate cyclase-C receptors, increasing fluid secretion in the intestines.

Irritable Bowel Syndrome with Constipation (IBS-C): A subtype of IBS characterized by abdominal pain and infrequent, hard bowel movements.

Chronic Idiopathic Constipation (CIC): Long-term constipation with no identifiable underlying cause.