Leukotrienes

Definition

Leukotrienes are inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid. They play a crucial role in the pathophysiology of asthma and allergic reactions.

5 Must Know Facts For Your Next Test

1. Leukotriene modifiers, such as montelukast, are used to treat asthma by blocking the effects of leukotrienes.
2. Leukotrienes increase vascular permeability, leading to edema and mucus secretion in respiratory pathways.
3. They are responsible for smooth muscle contraction in bronchioles, contributing to bronchoconstriction during an asthma attack.
4. Leukotriene receptor antagonists (LTRAs) and leukotriene synthesis inhibitors are two main types of leukotriene modifiers.
5. Common side effects of leukotriene modifiers include headache, gastrointestinal disturbances, and possible mood changes.

Review Questions

• What role do leukotrienes play in the pathophysiology of asthma?
• How do leukotriene modifiers help manage asthma symptoms?
• What are common side effects associated with leukotriene modifiers?

Related terms

Xanthines: A class of bronchodilators that includes drugs like theophylline used for treating respiratory disorders.

Mast Cell Stabilizers: Medications that prevent mast cells from releasing histamine and other inflammatory mediators.

Bronchoconstriction: The narrowing of the airways in the lungs due to tightening of surrounding smooth muscle.