Ivabradine

Definition

Ivabradine is a medication used to reduce heart rate in patients with certain types of chronic heart failure. It works by inhibiting the 'funny' (If) current in the sinoatrial node, thereby lowering the heart rate without affecting myocardial contractility.

5 Must Know Facts For Your Next Test

1. Ivabradine specifically targets and inhibits the If current in the sinoatrial node.
2. It is used primarily for patients with chronic heart failure who are in sinus rhythm and have a resting heart rate of at least 70 bpm.
3. Ivabradine can be beneficial for patients who cannot tolerate beta-blockers or need additional heart rate reduction despite maximal beta-blocker therapy.
4. Common side effects include bradycardia, hypertension, atrial fibrillation, and luminous phenomena (visual brightness).
5. Ivabradine should not be used in patients with acute decompensated heart failure, severe hepatic impairment, or significant hypotension.

Review Questions

• What specific cardiac current does Ivabradine inhibit?
• For which patient population is Ivabradine indicated in the context of chronic heart failure?
• Name two common side effects of Ivabradine.

Related terms

Beta-Blockers: Medications that reduce blood pressure and heart rate by blocking beta-adrenergic receptors.

Sinoatrial Node: The natural pacemaker of the heart that initiates each heartbeat.

Bradycardia: A slower than normal heart rate, typically defined as fewer than 60 beats per minute.