Inclisiran

Definition

Inclisiran is a small interfering RNA (siRNA) drug that targets PCSK9 mRNA, leading to decreased LDL cholesterol levels in the bloodstream. It is used primarily for patients with hypercholesterolemia who are at high risk of cardiovascular events.

5 Must Know Facts For Your Next Test

1. Inclisiran works by inhibiting the production of PCSK9, which increases the number of LDL receptors on liver cells.
2. It is administered via subcutaneous injection typically every six months after initial dosing.
3. Inclisiran has been shown to reduce LDL cholesterol levels by approximately 50% in clinical trials.
4. The drug provides an alternative for patients who do not respond adequately to statins or other lipid-lowering therapies.
5. Common side effects include injection site reactions, such as redness and pain.

Review Questions

• How does Inclisiran lower LDL cholesterol levels?
• What is the typical administration frequency for Inclisiran?
• For which patient population is Inclisiran primarily indicated?

Related terms

Statins: A class of drugs that inhibit HMG-CoA reductase, reducing cholesterol synthesis in the liver.

PCSK9 Inhibitors: Drugs that block PCSK9 protein, allowing more LDL receptors to remove cholesterol from the blood.

Lipoprotein: Molecules made of protein and fat that carry cholesterol through the bloodstream.