Glyburide/metformin

Definition

Glyburide/metformin is a combination oral antidiabetic drug that contains glyburide, a sulfonylurea, and metformin, a biguanide. It is used to improve blood glucose control in adults with type 2 diabetes.

5 Must Know Facts For Your Next Test

1. Glyburide stimulates insulin release from the pancreatic beta cells.
2. Metformin decreases hepatic glucose production and improves insulin sensitivity.
3. The combination of glyburide and metformin works synergistically to control blood sugar levels more effectively than either drug alone.
4. Common side effects include gastrointestinal issues such as nausea and diarrhea.
5. Patients should monitor for signs of hypoglycemia because glyburide can cause low blood sugar.

Review Questions

• What are the two main actions of glyburide/metformin in managing type 2 diabetes?
• Why is it important to monitor for signs of hypoglycemia when taking glyburide/metformin?
• What are common gastrointestinal side effects associated with glyburide/metformin?

Related terms

Sulfonylurea: A class of oral antidiabetic drugs that stimulate insulin release from pancreatic beta cells.

Biguanides: A class of oral antidiabetic drugs that reduce hepatic glucose production and increase insulin sensitivity.

Hypoglycemia: A condition characterized by abnormally low blood sugar levels, which can be a side effect of certain antidiabetic medications.