Glitazones

Definition

Glitazones, also known as thiazolidinediones, are a class of oral antidiabetic drugs that improve insulin sensitivity in peripheral tissues. They are primarily used to manage type 2 diabetes.

5 Must Know Facts For Your Next Test

1. Glitazones work by activating peroxisome proliferator-activated receptor-gamma (PPAR-γ) to enhance insulin sensitivity.
2. Common drugs in this class include pioglitazone and rosiglitazone.
3. They can cause side effects such as weight gain, edema, and increased risk of heart failure.
4. Glitazones may take several weeks to months for full therapeutic effect.
5. They are contraindicated in patients with severe heart failure or liver disease.

Review Questions

• What is the mechanism of action for glitazones?
• Name two common glitazone medications used in the treatment of type 2 diabetes.
• What are some potential side effects associated with glitazones?

Related terms

Insulin Sensitivity: The efficiency with which cells respond to the hormone insulin.

Type 2 Diabetes: A chronic condition that affects how the body metabolizes glucose.

PPAR-γ Agonists: Compounds that activate peroxisome proliferator-activated receptor-gamma, enhancing insulin sensitivity.