Evolocumab

Definition

Evolocumab is a monoclonal antibody used as an adjunct to diet and maximally tolerated statin therapy to reduce low-density lipoprotein cholesterol (LDL-C). It works by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9), which increases the number of LDL receptors available to clear LDL from the blood.

5 Must Know Facts For Your Next Test

1. Evolocumab is administered via subcutaneous injection.
2. It significantly lowers LDL-C levels, often by over 50%.
3. Evolocumab is typically used for patients with familial hypercholesterolemia or those who need additional LDL reduction despite maximum statin therapy.
4. Common side effects include nasopharyngitis, upper respiratory tract infections, and injection site reactions.
5. Clinical trials have shown that Evolocumab can reduce the risk of cardiovascular events.

Review Questions

• What is the mechanism of action of Evolocumab?
• For which patients is Evolocumab typically prescribed?
• What are some common side effects of Evolocumab?

Related terms

Statins: A class of drugs that inhibit HMG-CoA reductase, effectively lowering cholesterol levels.

PCSK9 Inhibitors: A class of drugs that lower LDL cholesterol by preventing PCSK9 from degrading LDL receptors.

Familial Hypercholesterolemia: A genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL).