Esomeprazole

Definition

Esomeprazole is a proton-pump inhibitor (PPI) used to reduce stomach acid production. It is commonly prescribed for conditions such as GERD, peptic ulcers, and Zollinger-Ellison syndrome.

5 Must Know Facts For Your Next Test

1. Esomeprazole works by irreversibly inhibiting the H+/K+ ATPase enzyme system in the stomach lining.
2. It is more effective when taken before meals, typically 30 minutes to an hour before eating.
3. Common side effects include headache, diarrhea, nausea, and abdominal pain.
4. Esomeprazole can interact with certain drugs like clopidogrel, reducing their effectiveness.
5. Long-term use of esomeprazole may lead to vitamin B12 deficiency and an increased risk of fractures.

Review Questions

• How does esomeprazole work to reduce stomach acid production?
• What are common side effects associated with esomeprazole use?
• Why should esomeprazole be taken before meals?

Related terms

Omeprazole: Another proton-pump inhibitor used to treat similar conditions as esomeprazole.

Histamine H2-receptor antagonists: A class of drugs that also reduce stomach acid but by blocking histamine receptors on parietal cells.

GERD (Gastroesophageal Reflux Disease): A chronic condition where stomach acid frequently flows back into the esophagus causing irritation.