Echinocandins

Definition

Echinocandins are a class of antifungal drugs that inhibit the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall. They are used primarily to treat invasive fungal infections such as candidiasis and aspergillosis.

5 Must Know Facts For Your Next Test

1. Echinocandins include drugs like caspofungin, micafungin, and anidulafungin.
2. These drugs are particularly effective against Candida species and Aspergillus species.
3. They are commonly administered intravenously due to poor oral bioavailability.
4. Echinocandins have fewer side effects compared to other antifungal agents, making them suitable for patients with compromised immune systems.
5. Resistance to echinocandins is relatively rare but can occur via mutations in the FKS genes of fungi.

Review Questions

• What component of the fungal cell wall do echinocandins target?
• Name three echinocandin drugs used in clinical practice.
• Why are echinocandins typically administered intravenously?

Related terms

Antifungal Drugs: Medications used to treat fungal infections by killing or inhibiting the growth of fungi.

Caspofungin: An echinocandin antifungal drug used to treat invasive candidiasis and aspergillosis.

β-(1,3)-D-glucan: A critical polysaccharide component of the fungal cell wall targeted by echinocandins.