Duloxetine

Definition

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used primarily to treat major depressive disorder and generalized anxiety disorder. It also has applications in managing chronic pain conditions such as fibromyalgia and neuropathy.

5 Must Know Facts For Your Next Test

1. Duloxetine works by increasing the levels of serotonin and norepinephrine in the brain, which helps improve mood and reduce anxiety.
2. Common side effects include nausea, dry mouth, drowsiness, and dizziness.
3. It is metabolized primarily in the liver via the cytochrome P450 enzyme system, particularly CYP1A2 and CYP2D6.
4. Abrupt discontinuation of Duloxetine can lead to withdrawal symptoms; hence, it should be tapered off rather than stopped suddenly.
5. Duloxetine is contraindicated in patients with uncontrolled narrow-angle glaucoma.

Review Questions

• What neurotransmitters are affected by Duloxetine?
• Name two conditions other than depression for which Duloxetine can be prescribed.
• Why is it important not to abruptly discontinue Duloxetine?

Related terms

Serotonin-Norepinephrine Reuptake Inhibitor (SNRI): A class of medications that increase levels of serotonin and norepinephrine in the brain.

Major Depressive Disorder: A mental health condition characterized by persistent feelings of sadness and loss of interest.

Fibromyalgia: A condition characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory, and mood issues.