Dronedarone

Definition

Dronedarone is an antiarrhythmic medication used to treat certain types of abnormal heart rhythms, specifically atrial fibrillation and atrial flutter. It works by blocking potassium channels among other mechanisms, which helps stabilize the heart's electrical activity.

5 Must Know Facts For Your Next Test

1. Dronedarone is classified as a Class III antiarrhythmic drug.
2. It is structurally related to amiodarone but lacks iodine atoms, reducing its toxicity.
3. Dronedarone is contraindicated in patients with severe heart failure or permanent atrial fibrillation due to increased mortality risk.
4. Common side effects include gastrointestinal disturbances, such as nausea and diarrhea.
5. It has a black box warning for use in patients with decompensated heart failure.

Review Questions

• What class of antiarrhythmic drugs does dronedarone belong to?
• Why is dronedarone contraindicated in patients with severe heart failure?
• What are common side effects associated with dronedarone?

Related terms

Atrial Fibrillation: An irregular, often rapid heart rate that can lead to poor blood flow.

Class III Antiarrhythmics: A category of drugs that predominantly block potassium channels to prolong repolarization.

Amiodarone: A potent Class III antiarrhythmic agent known for its efficacy and potential toxicities.