Doxazosin

Definition

Doxazosin is an alpha-1 adrenergic blocker used to treat hypertension and benign prostatic hyperplasia (BPH). It works by relaxing blood vessels and the muscles of the prostate and bladder neck, making it easier to urinate.

5 Must Know Facts For Your Next Test

1. Doxazosin is primarily used to manage symptoms of BPH and high blood pressure.
2. It works by blocking alpha-1 receptors, which causes vasodilation and relaxation of smooth muscle in the prostate.
3. Common side effects include dizziness, fatigue, and hypotension.
4. Patients should be cautioned about orthostatic hypotension, especially after the first dose or when increasing dosage.
5. Doxazosin can interact with other antihypertensive drugs, potentially leading to an excessive drop in blood pressure.

Review Questions

• What are the primary medical conditions treated by doxazosin?
• How does doxazosin work on a molecular level?
• What precautions should be taken when initiating or adjusting the dosage of doxazosin?

Related terms

Tamsulosin:

An alpha-1 blocker also used to treat BPH, but more selective for prostate receptors.

Finasteride:

A 5-alpha-reductase inhibitor used to reduce the size of an enlarged prostate.

Alpha Blockers:

A class of drugs that relax certain muscles and help small blood vessels remain open.