Dornase alfa

Definition

Dornase alfa is an enzyme medication used to break down and thin mucus in the lungs, improving airflow and reducing respiratory infections. It is commonly prescribed for patients with cystic fibrosis.

5 Must Know Facts For Your Next Test

1. Dornase alfa specifically targets DNA in mucus, breaking it down to reduce viscosity.
2. It is administered via nebulization, allowing direct delivery to the respiratory tract.
3. Patients often use Dornase alfa daily as part of their ongoing cystic fibrosis management.
4. Common side effects include voice alteration, sore throat, and rash.
5. Clinical studies have shown that regular use can improve lung function and decrease pulmonary exacerbations.

Review Questions

• What is the primary action of Dornase alfa on mucus?
• How is Dornase alfa typically administered to patients?
• What are some common side effects associated with Dornase alfa?

Related terms

Expectorants: Medications that help clear mucus from the airways by increasing its expulsion.

Mucolytics: Agents that break down the structure of mucus, making it thinner and easier to cough up.

Nebulization: A method of administering medication directly into the lungs through a mist inhaled via a nebulizer device.