Dopamine antagonists

Definition

Dopamine antagonists are drugs that block dopamine receptors, reducing the effects of dopamine in the brain. They are often used in the treatment of psychiatric disorders but can also impact treatments for Parkinson's Disease.

5 Must Know Facts For Your Next Test

1. Dopamine antagonists can exacerbate symptoms of Parkinson's Disease by further reducing dopamine activity.
2. These drugs may cause side effects such as tremors, rigidity, and bradykinesia, which are similar to Parkinsonian symptoms.
3. Common dopamine antagonists include antipsychotics like haloperidol and metoclopramide.
4. Dopamine antagonists are not typically used as a primary treatment for Parkinson’s Disease because they counteract dopaminergic therapies.
5. They may be prescribed cautiously in patients with both psychiatric conditions and Parkinson’s Disease to balance treatment outcomes.

Review Questions

• Why might dopamine antagonists worsen symptoms in patients with Parkinson's Disease?
• Name two common drugs that act as dopamine antagonists.
• What are some side effects associated with the use of dopamine antagonists in the context of Parkinson’s Disease?

Related terms

Levodopa: A precursor to dopamine used to treat symptoms of Parkinson’s Disease by increasing levels of dopamine in the brain.

Anticholinergics: Drugs that block acetylcholine receptors and may help reduce tremors and muscle stiffness in Parkinson’s Disease.

On-off phenomenon: Fluctuations between mobility and immobility experienced by patients with Parkinson's despite medication.