Dopamine agonist

Definition

Dopamine agonists are medications that mimic the effects of dopamine by stimulating dopamine receptors in the brain. They are primarily used to treat conditions like Parkinson’s disease and certain psychiatric disorders.

5 Must Know Facts For Your Next Test

1. Dopamine agonists can be used as monotherapy or in combination with other anti-Parkinsonian drugs.
2. Common side effects include nausea, dizziness, and hallucinations.
3. They are often preferred for younger patients with Parkinson's disease to delay the need for levodopa.
4. There are two main types: ergot derivatives (e.g., bromocriptine) and non-ergot derivatives (e.g., pramipexole, ropinirole).
5. Some dopamine agonists are also used to treat restless legs syndrome (RLS) and hyperprolactinemia.

Review Questions

• What is the primary therapeutic use of dopamine agonists?
• List two common side effects associated with dopamine agonists.
• Why might a physician choose a dopamine agonist over levodopa for a younger patient with Parkinson's disease?

Related terms

Levodopa:

A precursor to dopamine that is converted into dopamine in the brain, commonly used to treat Parkinson's disease.

MAO-B Inhibitors:

Medications that inhibit monoamine oxidase B, an enzyme that breaks down dopamine, thereby increasing its levels in the brain.

Antipsychotics: Medications used to manage psychosis, including schizophrenia and bipolar disorder; some may affect dopamine pathways.