MAO-B inhibitors

Definition

MAO-B inhibitors are medications that block the activity of monoamine oxidase B, an enzyme responsible for breaking down dopamine in the brain. They are primarily used to treat symptoms of Parkinson’s disease.

5 Must Know Facts For Your Next Test

1. MAO-B inhibitors help increase and prolong the effect of dopamine in the brain, which can improve motor symptoms in Parkinson's patients.
2. Common MAO-B inhibitors include selegiline and rasagiline.
3. These drugs can be used as monotherapy in early-stage Parkinson's or as an adjunct to levodopa in more advanced stages.
4. MAO-B inhibitors have fewer side effects compared to older treatments like MAO-A inhibitors, but they can still cause insomnia, nausea, and hallucinations.
5. Patients should avoid foods high in tyramine (like aged cheese) while taking MAO-B inhibitors to prevent hypertensive crises.

Review Questions

• What is the primary function of MAO-B inhibitors in treating Parkinson's disease?
• Name two common MAO-B inhibitors used in clinical practice.
• Why should patients on MAO-B inhibitors avoid foods high in tyramine?

Related terms

Levodopa:

A precursor to dopamine that is commonly used to treat Parkinson’s disease.

Monoamine Oxidase A (MAO-A) Inhibitors: A class of drugs that inhibit monoamine oxidase A, another enzyme involved in breaking down neurotransmitters.

Dopamine Agonists:

Medications that mimic dopamine by stimulating dopamine receptors directly.