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Diuril

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Pharmacology for Nurses

Definition

Diuril, also known as chlorothiazide, is a thiazide diuretic used to treat hypertension and fluid retention associated with heart failure. It works by inhibiting sodium reabsorption in the distal convoluted tubules of the kidney.

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5 Must Know Facts For Your Next Test

  1. Diuril increases the excretion of sodium and water, thereby reducing blood volume and lowering blood pressure.
  2. It is typically administered orally but can also be given intravenously in certain cases.
  3. Common side effects include electrolyte imbalances, such as hypokalemia (low potassium levels), and dehydration.
  4. Diuril may interact with other medications, including lithium and digoxin, potentially enhancing their effects or toxicity.
  5. Patients taking Diuril are often advised to monitor their blood pressure regularly and maintain adequate hydration.

Review Questions

  • What is the primary mechanism of action for Diuril?
  • Name two common side effects associated with Diuril.
  • Why might a patient on Diuril need to monitor their potassium levels?

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