Pharmacology for Nurses

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Cytarabine

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Pharmacology for Nurses

Definition

Cytarabine is a chemotherapeutic agent used primarily to treat hematological malignancies like leukemia. It works by inhibiting DNA synthesis in rapidly dividing cancer cells.

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5 Must Know Facts For Your Next Test

  1. Cytarabine is most commonly used to treat acute myeloid leukemia (AML).
  2. It is an antimetabolite drug that mimics the structure of cytosine, a component of DNA.
  3. Administered intravenously, subcutaneously, or intrathecally depending on the type and stage of cancer.
  4. Common side effects include bone marrow suppression, gastrointestinal disturbances, and neurotoxicity.
  5. It is often used in combination with other chemotherapeutic agents to enhance efficacy.

Review Questions

  • What type of cancers is Cytarabine primarily used to treat?
  • How does Cytarabine inhibit cancer cell growth?
  • List three common side effects of Cytarabine.

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