Corlanor

Definition

Corlanor (ivabradine) is a medication used to reduce the heart rate in patients with chronic heart failure. It works by inhibiting the 'funny' current (If) in the sinoatrial node, leading to slower heart rate without affecting myocardial contractility.

5 Must Know Facts For Your Next Test

1. Corlanor is used specifically for patients with stable, symptomatic chronic heart failure who have a resting heart rate of at least 70 beats per minute.
2. It is indicated for those who are either on maximally tolerated doses of beta-blockers or have a contraindication to beta-blocker use.
3. Common side effects include bradycardia, hypertension, atrial fibrillation, and visual disturbances such as luminous phenomena (phosphenes).
4. Corlanor should not be used in patients with acute decompensated heart failure, severe hepatic impairment, or those dependent on pacemakers.
5. The dosing of Corlanor is typically adjusted based on heart rate monitoring; the goal is to achieve a resting heart rate between 50-60 beats per minute.

Review Questions

• What is the primary mechanism of action of Corlanor?
• Which patient population is Corlanor specifically indicated for?
• List two common side effects associated with Corlanor.

Related terms

Beta-Blockers: A class of drugs that reduce blood pressure and improve heart function by blocking adrenaline receptors.

Heart Failure: A condition where the heart cannot pump enough blood to meet the body's needs.

Sinoatrial Node: The natural pacemaker of the heart responsible for initiating electrical impulses that regulate heartbeat.