Chlorthalidone

Definition

Chlorthalidone is a thiazide-like diuretic used to treat hypertension and edema associated with heart failure. It works by inhibiting sodium reabsorption in the distal convoluted tubule of the kidney.

5 Must Know Facts For Your Next Test

1. Chlorthalidone increases the excretion of sodium and water, reducing blood volume and pressure.
2. It has a longer half-life compared to hydrochlorothiazide, making it effective for once-daily dosing.
3. Common side effects include hypokalemia, hyperglycemia, and dizziness.
4. Chlorthalidone may interact with other antihypertensive drugs, enhancing their effects.
5. It is often used as part of combination therapy for more effective blood pressure control.

Review Questions

• What is the primary mechanism of action for Chlorthalidone?
• List three common side effects of Chlorthalidone.
• How does Chlorthalidone differ from hydrochlorothiazide in terms of dosing frequency?

Related terms

Hydrochlorothiazide:

A thiazide diuretic commonly used to treat hypertension and edema.

Furosemide:

A loop diuretic that inhibits sodium reabsorption in the ascending loop of Henle.

Spironolactone:

A potassium-sparing diuretic that antagonizes aldosterone receptors to reduce fluid retention.