Chlorpropamide

Definition

Chlorpropamide is a first-generation sulfonylurea used to treat type 2 diabetes mellitus. It works by stimulating the release of insulin from the pancreas.

5 Must Know Facts For Your Next Test

1. Chlorpropamide has a long duration of action, typically lasting up to 60 hours.
2. It can cause hypoglycemia as a common side effect, especially in elderly patients.
3. Alcohol consumption should be avoided while taking chlorpropamide due to the risk of a disulfiram-like reaction.
4. Chlorpropamide is metabolized by the liver and excreted by the kidneys; dose adjustments may be necessary in hepatic or renal impairment.
5. It may interact with other drugs such as diuretics, corticosteroids, and beta-blockers.

Review Questions

• What is the primary mechanism of action for chlorpropamide?
• Why should alcohol consumption be avoided when taking chlorpropamide?
• What are some common drug interactions that nurses should monitor for patients on chlorpropamide?

Related terms

Hypoglycemia:

A condition caused by low blood glucose levels, often a side effect of diabetes medications like chlorpropamide.

Sulfonylureas:

A class of medications that stimulate insulin release from pancreatic beta cells to lower blood sugar levels.

Type 2 Diabetes Mellitus: A chronic condition characterized by insulin resistance and impaired insulin secretion.