Calcitonin gene related peptide (CGRP) receptor antagonists

Definition

Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of medications used to prevent and treat migraine headaches. They work by blocking the action of CGRP, a neuropeptide involved in migraine pathophysiology.

5 Must Know Facts For Your Next Test

1. CGRP receptor antagonists are specifically designed to prevent migraines and reduce their severity.
2. These drugs can be administered via oral tablets or injections depending on the specific medication.
3. Common side effects include nausea, constipation, and injection site reactions.
4. Some examples of CGRP receptor antagonists include erenumab, fremanezumab, and galcanezumab.
5. CGRP plays a key role in migraine attacks by promoting vasodilation and inflammation in the brain.

Review Questions

• What is the primary mechanism of action for CGRP receptor antagonists?
• Name two common side effects associated with CGRP receptor antagonists.
• List three examples of medications that belong to the CGRP receptor antagonist class.

Related terms

Migraine Headache: A neurological condition characterized by intense, debilitating headaches often accompanied by nausea, vomiting, and sensitivity to light or sound.

Neuropeptide: Small protein-like molecules used by neurons to communicate with each other; they influence numerous bodily functions including pain perception.

Vasodilation: The widening of blood vessels which decreases blood pressure; it is a process involved in the development of migraines.